研究業績 Publications

2024

• Greetings from virologists to mycologists: A review outlining viruses that live in fungi
  Urayama S, Zhao Y-J, Kuroki M, Chiba Y, Ninomiya A, Hagiwara D
  Mycoscience 2024, 65, 1-11.

2023

• Identification of glycine betaine as a host-derived molecule required for the vegetative proliferation of the protozoan parasite Perkinsus olseni
  Liu Y, Ninomiya A, Yoshinaga T, Ito N
  Parasitology 2023, 150, 939-949.


• Removal of weed algal contamination in cultures of Botryococcus braunii with enlarged colonies using rotifers
  Furuhashi K, Takata R, Hasegawa F, Okada S, Kaizu Y, Imou K
  Algal Res. 2023, 76, 103310.

2022

• Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium
  Ueoka R, Sondermann P, Leopold-Messer S, Liu Y, Suo R, Bhushan A, Vadakumchery L, Greczmiel U, Yashiroda Y, Kimura H, Nishimura S, Hoshikawa Y, Yoshida M, Oxenius A, Matsunaga S, Williamson RT, Carreira EM, Piel J
  Nat. Chem. 2022, 14, 1193-1201.




• Thinning of Botryococcus braunii colony sheath by pretreatment enhances solvent-based hydrocarbon recovery
  Furuhashi K, Magota A, Liu Y, Hasegawa F, Okada S, Kaizu Y, Imou K
  Phycology 2022, 2, 363-373.



• 二宮章洋 古くて新しい，糸状菌からの「もの取り」の話 生物工学 2022, 100, No.6, 316.
• Aciculitin D, a cytotoxic heterodetic cyclic peptide from a Poecillastra sp. marine sponge
  Sugawara K, Kanki D, Watanabe R, Matsushima R, Ise Y, Yokose H, Morii Y, Yamawaki N, Ninomiya A, Okada S, Matsunaga S
  Tetrahedron 2022, 119, 132859.


• Antibacterial diphenyl ether production induced by co-culture of Aspergillus nidulans and Aspergillus fumigatus
  Ninomiya A, Urayama S, Hagiwara D
  Appl. Microbiol. Biotechnol. 2022, 106, 4169-4185.


• Single-cell metabolite detection and genomics reveals uncultivated talented producer
  Kogawa M, Miyaoka R, Hemmerling F, Ando M, Yura K, Ide K, Nishikawa Y, Hosokawa M, Ise Y, Cahn JKB, Takada K, Matsunaga S, Mori T, Piel J, Takeyama H
  PNAS Nexus 2022, 1, pgab007.

2021

• Homophymamide A, Heterodetic Cyclic Tetrapeptide from a Homophymia sp. Marine Sponge: A Cautionary Note on Configurational Assignment of Peptides That Contain a Ureido Linkage
  Kanki D, Nakamukai S, Ogura Y, Takikawa H, Ise Y, Morii Y, Yamawaki N, Takatani T, Arakawa O, Okada S, Matsunaga S
  J. Nat. Prod. 2021, 84, 1848-1853.



• Structure Elucidation of Calyxoside B, a Bipolar Sphingolipid from a Marine Sponge Cladocroce sp. through the Use of Beckmann Rearrangement
  Sugawara K, Watarai H, Ise Y, Yokose H, Morii Y, Yamawaki N, Okada S, Matsunaga S
  Mar. Drugs 2021, 19, 287.


• Oshimalides A and B, Sesterterpenes of the Manoalide Class from a Luffariella sp. Deep-Sea Marine Sponge: Application of Asymmetric Dihydroxylation in Structure Elucidation
  Kanki D, Imai K, Ise Y, Okada S, Matsunaga S
  J. Nat. Prod. 2021, 84, 1676-1680.


• Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge Myrmekioderma sp.
  Moosman P, Taniguchi T, Furihata K, Utsumi H, Ise Y, Morii Y, Yamawaki N, Takatani T, Arakawa O, Okada S, Matsunaga S
  Org. Lett. 2021, 23, 3477-3480.


• Large-scale screening of natural genetic resource in the hydrocarbon-producing microalga Botrycoccus braunii identified novel fast-growing strains
  Kawamura K, Nishikawa S, Hirano K, Ardianor A, Nugroho RA, Okada S
  Sci. Rep. 2021, 11, 7368.

2020

• Microsclerodermins N and O, cytotoxic cyclic peptides containing a p-ethoxyphenyl moiety from a deep-sea marine sponge Pachastrella sp.
  Tian T, Takada K, Ise Y, Ohtsuka S, Okada S, Matsunaga S
  Tetrahedron 2020, 76, 130997.


• Heptavalinamide A, an Extensively N-Methylated Linear Nonapeptide from a Cyanobacterium Symploca sp. and Development of a Highly Sensitive Analysis of N,N-Dimethylvaline by LCMS
  Suo R, Watanabe R, Takada K, Suzuki T, Oikawa H, Itoi S, Sugita H, Matsunaga S
  Org. Lett. 2020, 22, 1254-1258.



• Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression
  Hitora Y, Takada K, Ise Y,Woo SP, Inoue S, Mori N, Takikawa H, Nakamukai S, Okada S, Matsunaga S
  Bioorg. Med. Chem. 2020, 28, 115233.

2019

• Detection of the oil-producing microalga Botryococcus braunii in natural freshwater environments by targeting the hydrocarbon biosynthesis gene SSL-3
  Hirano K, Hara T, Ardianor, Nugroho R A, Segah H, Takayama N, Sulmin G, Komai Y, Okada S, Kawamura K
  Sci. Rep. 2019, 9, 16974.



• Isolation and identification of N6-isopentenyladenosine as the cytotoxic constituent of a marine sponge Oceanapia sp.
  Nakamukai S, Ise Y, Ohtsuka S, Okada S, Matsunaga S
  Biosci. Biotechnol. Biochem. 2019, 83, 1985-1988.

2018

• Docking analysis of models for 4-hydroxy-3-methylbut-2-enyl diphosphate reductase and a ferredoxin from Botryococcus braunii, race B
  Uchida H, Mizohata E, Okada S
  Plant Biotechnol. 2018, 35, 297-301.


• Isolation and characterization of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene from Botryococcus braunii, race B
  Uchida H, Sumimoto K, Oki T, Nishii I, Mizohata E, Matsunaga S, Okada S
  J. Plant Res. 2018, 131, 839-848.


• 3D reconstruction of endoplasmic reticulum in a hydrocarbon-secreting green alga, Botryococcus braunii (Race B)
  Suzuki R, Nishii I, Okada S, Noguchi T
  Planta 2018, 247, 663-677.


• Colony-wise Analysis of a Theonella swinhoei Marine Sponge with a Yellow Interior Permitted the Isolation of Theonellamide I
  Fukuhara K, Takada K, Watanabe R, Suzuki T, Okada S, Matsunaga S
  J. Nat. Prod. 2018, 81, 2595-2599


• Poecillastrin H, a Chondropsin-Type Macrolide with a Conjugated Pentaene Moiety, from a Characella sp. Marine Sponge
  Suo R, Takada K, Irie R, Watanabe R, Suzuki T, Ise Y, Ohtsuka S, Okada S, Matsunaga S
  J. Nat. Prod. 2018, 81, 1295-1299.


• Stellatolide H, a cytotoxic peptide lactone from a deep-sea sponge Discodermia sp.
  Nakamukai S, Takada K, Furihata K, Ise Y, Okada S, Morii Y, Yamawaki N, Takatani T, Arakawa O, Gustafson KR, Matsunaga S
  Tetrahedron Lett. 2018, 59, 2532-2536.


• Miuramides A and B, Trisoxazole Macrolides from a Mycale sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells
  Suo R, Takada K, Kohtsuka H, Ise Y, Okada S, Matsunaga S
  J. Nat. Prod. 2018, 81, 1108-1112.


• Lactomycins A-C, Dephosphorylated Phoslactomycin Derivatives that　Inhibit Cathepsin B, from the Marine-derived Streptomyces sp. ACT232
  Sun Y, Carandang R R, Harada Y, Okada S, Yoshitake K, Asakawa S, Nogi Y, Matsunaga S, Takada K
  Mar Drugs 2018, 16, 70.



• Poecillastrin E, F, and G, cytotoxic chondropsin-type macrolides from a marine sponge Poecillastra sp.
  Irie R, Hitora Y, Ise Y, Okada S, Takada K, Matsunaga S
  Tetrahedron 2018, 74, 1430-1434.


• Molecular cloning and functional characterization of NADPH-dependent cytochrome P450 reductase from the green microalga Botryococcus braunii, B race
  Tsou C-Y, Matsunaga S, Okada S
  J. Biosci. Bioeng. 2018, 125, 30-37

2017

• Structure Revision of Poecillastrin C and the Absolute Configuration of the β-Hydroxyaspartic Acid Residue
  Irie R, Takada K, Ise Y, Ohtsuka S, Okada S, Gustafson K, Matsunaga S
  Org. Lett. 2017, 19, 5395-5397.    論文の要旨


• Resolution of the Confusion in the Assignments of Configuration for the Ciliatamides, Acylated Dipeptides from Marine Sponges
  Takada K, Irie R, Suo R, Matsunaga S
  J. Nat. Prod.2017, 80,2845-2849.


• An exception among diatoms: Unique organization of genes involved in isoprenoid biosynthesis in Rhizosolenia setigera CCMP 1694
  Ferriols VMEN, Yaginuma-Suzuki R, Fukunaga K, Kadono T, Adachi M, Matsunaga S, Okada S
  The Plant J 2017, 92, 822-833



• Draft nuclear genome sequence of the liquid hydrocarbon?accumulating green microalga Botryococcus braunii race B (Showa)
  Browne DR, Jenkins J, Schmutz J, Shu S, Barry K, Grimwood J, Chiniquy J, Sharma A, Niehaus TD, Weiss TL, Koppisch AT, Fox DT, Dhungana S, Okada S, Chappell J, Devarennea TP
  Genome Announc. 2017, 5, e00215-17




• Isolation and characterization of cyclic C33 botryococcenes and a trimethylsqualene isomer from Botryococcus braunii race B
  Tatli M, Naik MT, Okada S, Dangott LJ, Devarenne TP
  J. Nat. Prod. 2017, 80, 953-958.


• Utilization of ammonium by the hydrocarbon-producing microalga, Botryococcus braunii Showa
  Nakamura H, Shiozaki T, Gonda N, Furuya K, Matsunaga S, Okada S
  Algal Res. 2017, 25, 445-451.


• Dereplication of peptidic natural products through database search of mass spectra
  Mohimani H, Gurevich A, Mikheenko A, Garg N, Nothias L-F, Ninomiya A, Takada K, Dorrestein PC, Pevzner PA
  Nat. Chem. Biol. 2017, 13, 30-37.

2016

• Effects of 2-azahypoxanthine on extracellular terpene accumulations by the green microalga Botryococcus braunii, race B
  Nakamura H, Matsunaga S, Kawagishi H, Okada S
  Algal Res. 2016, 20, 267-275.


• Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge.
  Hitora Y, Takada K, Ise Y, Okada S, Matsunaga S.
  J. Nat. Prod. 2016, 79, 2973-2976.


• UV-mediated Chlamydomonas mutants with enhanced nuclear transgene expression by disruption of DNA methylationdependent and independent silencing systems
  Kurniasih S D, Yamasaki T, Kong F, Okada S, Widyaningrum D, Ohama T.
  Plant Mol. Biol. 2016, 92, 629-641.


• Taxonomic confirmation of mud crab species (genus Scylla) in Bangladesh by nuclear and mitochondrial DNA markers
  Sarower M G, Shahriar S I M, Nakamura H, Rouf M A, Okada S.
  Mitochondrial DNA Part A in press


• Effects of culture medium salinity on the hydrocarbon extractability, growth and morphology of Botryococcus braunii
  Furuhashi K, Hasegawa F, Saga K, Kudou S, Okada S, Kaizu Y, Imou K.
  Biomass Bioenerg. 2016, 91, 83-90


• The surface structure of Botryococcus braunii colony prevents the entry of extraction solvents into the colony interior
  Furuhashi K, Noguchi T, Okada S, Hasegawa F, Kaizu Y, Imou K.
  Algal Res. 2016, 16, 160-166


• Expression profile of genes involved in isoprenoid biosynthesis in the marine diatom Phaeodactylum tricornutum
  Kira N, Yoshimatsu T, Fukunaga K, Okada S, Adachi M, Kadono T.
  Environ. Control Biol. 2016, 54, 31-37


• Curacin E from the Brittle Star Ophiocoma scolopendrina
  Ueoka R, Hitora Y, Ito A, Yoshida M, Okada S, Takada K, Matsunaga S.
  J. Nat. Prod. 2016, 79, 2754-2757


• Yakushinamides, polyoxygenated fatty acid amides that inhibit HDACs and SIRTs, from a Marine Sponge Theonella swinhoei
  Takada K, Imae Y, Ise Y, Ohtsuka S, Ito A, Okada S, Yoshida M, Matsunaga S.
  J. Nat. Prod. 2016, 79, 2384-2390


• Biosynthetic Gene Cluster for Surugamide A Encompasses an Unrelated Decapeptide, Surugamide F.
  Ninomiya A, Katsuyama Y, Kuranaga T, Miyazaki M, Nogi Y, Okada S, Wakimoto T, Ohnishi Y, Matsunaga S, Takada K
  ChemBiochem 2016, 17, 1709-1712    論文の要旨



• Nazumazoles D-F, Cyclic Pentapeptides That Inhibit Chymotrypsin, from the Marine Sponge Theonella swinhoei.
  Fukuhara K, Takada K, Okada, S, Matsunaga, S.
  J. Nat. Prod. 2016, 79, 1694-1697    論文の要旨


• A squalene synthase-like enzyme initiates production of tetraterpenoid hydrocarbons in Botryococcus braunii Race L
  Thapa H.R., Naik M.T., Okada S., Takada K., Molnar I., Xu Y., Devarenne T.P.
  Nat. Comm. 2016, 7, 11198


• Rectified Proton Grotthuss Conduction Across a Long Water-Wire in the Test Nanotube of the Polytheonamide B Channel
  Matsuki Y., Iwamoto M., Mita K., Shigemi K., Matsunaga S., Oiki S.
  J. Am. Chem. Soc. 2016, 138, 4168-4177

2015

• Effect of an introduced phytoene synthase gene expression on carotenoid biosynthesis in the marine diatom Phaeodactylum tricornutum
  Kadono T, Kira N, Suzuki K, Iwata O, Ohama T, Okada S, Nishimura T, Akakabe M, Tsuda M, Adachi M.
  Mar. Drugs 2015, 13, 5334-5357



• Cytotoxic Glycosylated Fatty Acid Amides from a Stelletta sp. Marine Sponge
  Peddie V, Takada K, Shujiro Okuda, Ise Y, Morii Y, Yamawaki N, Takatani T, Arakawa O, Okada S, Matsunaga S.
  J. Nat. Prod. 2015, 78, 2808-2813


• Cytotoxic Linear Acetylenes from a Marine Sponge Pleroma sp.
  Takanashi E, Takada K, Hashimoto M, Itoh Y, Ise Y, Otsuka S, Okada S., Matsunaga S.
  Tetrahedron 2015, 71, 9564-9570


• Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms.
  Ueoka R, Uria AR, Reiter S, Mori T, Karbaum P, Peters EE, Helfrich EJ, Morinaka BI, Gugger M, Takeyama H, Matsunaga S, Piel J.
  Nat. Chem. BIol. 2015, 11, 705-712.


• Elucidation and Total Synthesis of the Correct Structures of Tridecapeptides Yaku'amides A and B. Synthesis-Driven Stereochemical Reassignment of Four Amino Acid Residues.
  Kuranaga T, Mutoh H, Sesoko Y, Goto T, Matsunaga S, Inoue M.
  J.Am.Chem.Soc. 2015, 137, 9443.-9451.


• Two cell differentiation inducing pyridoacridines from a marine sponge Biemna sp. and their chemical conversions
  Pedrazzoli Moran DA, Takada K, Ise Y, Bontemps N, Davis RA, Furihata K, Okada S, Matsunaga S
  Tetrahedron 2015, 71, 5013-5018.



• Robust expression of heterologous genes by selection marker fusion system in improved Chlamydomonas strains
  Kong F, Yamasaki T, Kumiasih SD, Hou L, Li X, Ivanova N, Okada S, Ohama T
  J. Biosci. Bioeng. 2015, in press


• Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera
  Ferriols VMEN, Yaginuma R, Adachi M, Takada K, Matsunaga, S, Okada S
  Sci. Rep. 2015, 5, 10246


• Nazumazoles A-C, Cyclic Pentapeptides Dimerized through a Disulfide Bond from the Marine Sponge Theonella swinhoei
  Fukuhara K, Takada K, Okada S, Matsunaga S
  Org. Lett. 2015, 17, 2646-2648


• Effect of amphiphilic polysaccharides released from Botryococcus braunii Showa on hydrocarbon recovery
  Atobe S, Saga K, Hasegawa F, Furuhashi K, Tashiro Y, Suzuki T, Okada S, Imou K
  Algal Res. 2015, 10, 172-176


• Comparative evaluation of wet and dry processes for recovering hydrocarbon from Botryococcus Braunii
  Saga K, Hasegawa F, Miyagi S, Atobe S, Okada S, Imou K, Osaka N, Yamagishi T
  Appl. Energ. 2015, 141, 90-95


• Targeting cholesterol in a liquid-?disordered environment by theonellamides modulates cell membrane order and cell shape
  Arita Y, Nishimura S, Ishitsuka R, Kishimoto T, Ikenouchi J, Ishii K, Umeda M, Matsunaga S, Kobayashi T, Yoshida M
  Chem. Biol. 2015, 22, 604-610



• Isolation and Characterization of Two Squalene Epoxidase Genes from Botryococcus braunii, Race B
  Uchida H, Sumimoto K, Ferriols VMEN, Imou K, Saga, K, Furuhashi, Matsunaga S, Okada S
  PLOS ONE 2015, 10, e0122649     論文の要旨
  

2014

• Paradoxical one-ion pore behavior of the long β-helical peptide of marine cytotoxic polytheonamide B
  Iwamoto M, Matsunaga S, Oiki S
  Sci. Rep. 2014, 4, 3636


• Culture of the green microalga Botryococcus braunii Showa with LED irradiation eliminating violet light enhances hydrocarbon production and recovery
  Atobe S, Saga K, Maeyama H, Fujiwara K, Okada S, Imou K
  Biosci. Biotechnol. Biochem. 2014, 78, 1765-1771


• The effect of the water-soluble polymer released from Botryococcus braunii Showa strain on solvent extraction of hydrocarbon
  Atobe S, Saga K, Hasegawa F, Magota A, Furuhashi K, Okada S, Suzuki T, Imou K
  J. Appl. Phycol. 2014 Published online


• Structural reappraisal of corticatic acids, biologically active linear polyacetylenes, from a marine sponge of the genus Petrosia
  Takada K, Okada S, Matsunaga S
  Fish. Sci. 2014, 80, 1057-1064


• Lower Homologues of Ahpatinin, Aspartic Protease Inhibitors, from a Marine Streptomyces sp.
  Sun Y, Takada K, Nogi Y, Okada S, Matsunaga S.
  J. Nat. Prod. 2014, 77, 1749-1752


• Sequestered Fulvinol-related Polyacetylenes in Peltodoris atromaculata.
  Ciavatta M.L., Nuzzo G., Takada K., Mathieu V., Kiss R., Villani G, Gavagnin M.
  J. Nat. Prod. 2014, 77, 1678-1684


• Release of single cells from the colonial oil-producing alga Botryococcus braunii by chemical treatments
  Hou L, Park H, Okada S, Ohama T
  Protoplasma 2014, 251,191-199


• An environmental bacterial taxonwith a large and distinct metabolic repertoire.
  M. C. Wilson, T. Mori, C. Ruckert, A. R. Uria, M. J. Helf, K. Takada, C. Gernert, U. Steffens, N. Heycke, S. Schmitt, C. Rinke, E. J. N. Helfrich, A. O. Brachmann, C. Gurgui, T. Wakimoto, M. Kracht, M. Crusemann, U. Hentschel, I. Abe, S. Matsunaga, J. Kalinowski, H. Takeyama, J. Piel
  Nature 2014, 506, 58-62     農学部・プレスリリース




• Chemoenzymatic synthesis and HPLC analysis of the stereoisomers of miyakosyne A [(4E,24E)-14-methyloctacosa-4,24-diene-1,27-diyne-3,26-diol], a cytotoxic metabolite of a marine sponge Petrosia sp., to determine the absolute configuration of its major component as 3R,14R,26R
  Mori K, Akasaka K, Matsunaga S
  Tetrahedron 2014, 70, 392-401　   Chem-Station 解説記事




• Revised Structure of Cyclolithistide A, a Cyclic Depsipeptide from the Marine Sponge Discodermia japonica
  Tajima H, Wakimoto T, Takada K, Ise Y, Abe I
  J. Nat. Prod. 2014, 77, 154-158.

2013

• Transformation of lipid bodies related to hydrocarbon accumulation in a green alga, Botryococcus braunii (Race B)
  Suzuki R, Ito N, Uno Y, Nishi I, Kagiwada S, Okada S, Noguchi T
  PLOS ONE 2013, 8, e81626


• Visualization of Sterol-Rich Membrane Domains with Fluorescently-Labeled Theonellamides
  Nishimura S, Ishii K, Iwamoto K, Arita Y, Matsunaga S, Ohno-Iwashita Y, Sato S, Kakeya H, Kobayashi T, Yoshida M
  PLOS ONE 2013, 8, e83716



• On the Assignment of the Absolute Configuration at the Isolated Methyl Branch in Miyakosyne A, Cytotoxic Linear Acetylene, from the Deep-Sea Marine Sponge Petrosia sp.
  Hitora Y, Takada K, Matsunaga S
  Tetrahedron 2013, 69, 11070-11073.    Chem-Station 解説記事


• Cycloforskamide, a Cytotoxic Macrocyclic Peptide from the Sea Slug Pleurobranchus forskalii.
  Tan K, Wakimoto T, Takada K, Ohtsuki T, Uchiyama N, Goda Y, Abe Y.
  J. Nat. Prod 2013, 76, 1388-1391


• Seawater-cultured Botryococcus braunii for Efficient Hydrocarbon Extraction.
  Furuhashi K, Saga S, Okada S, Imou K.
  PLOS ONE 2013, 8, e66483
• Active Hydrocarbon Biosynthesis and Accumulation in a Green Alga, Botryococcus braunii (Race A)
  Hirose M, Mukaida F, Okada S, Noguchi T.
  Eukaryotic Cell 2013, 12, 1132-1141


• Surugamides A-E, Cyclic Octapeptides with Four D-Amino Acid Residues, from a Marine Streptomyces sp.: LC-MS-Aided Inspection of Partial Hydrolysates for the Distinction of D- and L-Amino Acid Residues in the Sequence.
  Takada K*, Ninomiya A*, Naruse M, Sun Y, Miyazaki M, Nogi Y, Matsunaga S
  J. Org Chem 2013, 78, 6746-6750.  (* equally contributed)



• Stimulators of adipogenesis from the marine sponge Xestospongia testudinaria.
  Akiyama T, Takada K, Oikawa T, Matsuura N, Ise Y, Okada S, Matsunaga S
  Tetrahedron 2013, 69, 6560-6564.
• X-ray analysis on the nanogram-microgram scale using porous complexes.
  Inokuma Y, Yoshioka S, Ariyoshi J, Arai T, Hitora Y, Takada K, Matsunaga s, Rissanen K, Fujita M.
  Nature 2013, 495, 461-466   Chem-Station 解説記事


• Interaction between the Marine Sponge Cyclic Peptide Theonellamide A and Sterols in Lipid Bilayers As Viewed by Surface Plasmon Resonance and Solid-?State
  Espiritu RA, Matsumori N, Murata M, Nishimura S, Kakeya H, Matsunaga S, Yoshida M
  Biochemistry 2013, 52, 2410-2418.


• Isolation of Ciliatamide D from a Marine Sponge Stelletta sp. and a Reinvestigation of the Configuration of Ciliatamide A.
  Imae Y, Takada K, Okada S, Ise Y, Morii Y, Yoshimura H, Matsunaga S.
  J. Nat. Prod. 2013, 76, 755-758.


• Culture of the hydrocarbon producing microalga Botryococcus braunii strain Showa: Optimal CO2, salinity, temperature, and irradiance conditions.
  Yoshimura T, Okada S, Honda M.
  Biores. Technol. 2013, 133, 232-239.


• Wet extraction of hydrocarbons from Botryococcus braunii by dimethyl ether as compared with dry extraction by hexane.
  Kanda H, Li P, Yoshimura T, Okada S.
  Fuel 2013, 105, 535-539


• 高田健太郎, 松永茂樹　カイメン由来の多彩な二次代謝産物と共生微生物の関係 化学と生物 2013, 51, No.5, 333-339

2012

• Effect of thermal pretreatments on hydrocarbon recovery from Botryococcus braunii.
  Magota A, Saga K, Okada S, Atobe S, Imou K.
  Biores. Technol. 2012, 123, 195-198.
• Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides.
  Freeman MF,Gurgui C,Helf MJ, Morinaka BI, Uria AR, Oldham NJ, Sahl H-G, Matsunaga S, Piel J.
  Science 2012, 338, 387-390. 論文の要旨
  



• Isolation of Spirastrellolides A and B from a Marine Sponge Epipolasis sp. and Their Cytotoxic Activities.
  Suzuki M, Ueoka R, Takada K, Okada S, Ohtsuka S, Ise Y, Matsunaga S.
  J. Nat. Prod. 2012, 75, 1192-1195.


• The single cellular green microalga Botryococcus braunii, race B possesses three distinct 1-deoxy-d-xylulose 5-phosphate synthases.
  Matsushima D, Jenke-Kodama H, Sato Y, Fukunaga Y, Sumimoto K, Kuzuyama T, Matsunaga S, Okada S.
  Plant Sci. 2012, 185-186, 309-320.


• Functional Identification of Triterpene Methyltransferases from Botryococcus braunii race B.
  Niehaus T, Kinison S, Okada S, Yeo YS, Bell SA, Cui P, Devarenne TP, Chappell J.
  J Biol. Chem. 2012,287,8163-8173.


• Gliotoxin Analogues from a Marine-Derived Fungus, Penicillium sp., and Their Cytotoxic and Histone Methyltransferase Inhibitory Activities.
  Sun, Y, Takada K, Takemoto Y, Yoshida M, Nogi Y, Okada S, Matsunaga S
  J. Nat. Prod. 2012, 75, 111-114.

2011

• Imae Y, Takada K, Murayama S, Okada S, Ise Y, Matsunaga S Jasisoquinolines A and B, Architecturally New Isoquinolines, from a Marine Sponge Jaspis sp. Org.Lett. 2011, 13, 4798-4801.
• Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J. Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. Proc. Natl. Acad. Sci. USA. 2011, 108, 12260-12265.
• Eroglu E, Okada S, Melis A. Hydrocarbon productivities in different Botryococcus strains: comparative methods in product quantification. J. Appl. Phycol. 2011, 23, 763-775.
  
• Murayama S, Imae Y, Takada K, Kikuchi J, Nakao Y, van Soest RW, Matsunaga S.  Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata.  Bioorg. Med. Chem.  2011, 19, 6594-6598.
  
• Hitora Y, Takada K, Okada S, Matsunaga S.  Miyakosynes A-F, cytotoxic methyl branched acetylenes from a marine sponge Petrosia sp.  Tetrahedron  2011, 67, 4530-4534.
  
• Hitora Y, Takada K, Okada S, Ise Y, Matsunaga S.  (-)-Duryne and its Homologues, Cytotoxic Acetylenes from a Marine Sponge Petrosia sp.  J. Nat. Prod.  2011, 74, 1262-1267.

2010

• Weiss TL, Chun HJ, Okada S, Vitha S, Holzenburg A, Laane J, Devarenne TP. Raman spectroscopy analysis of botryococcene hydrocarbons from the green microalga Botryococcus braunii. J. Biol. Chem. 2010, 285, 32458-32466.
• Kita K, Okada S, Sekino H, Imou, K, Yokoyama S, Amano T. Thermal pre-treatment of wet microalgae harvest for efficient hydrocarbon recovery. Appl. Energ. 2010, 87, 2420-2423.
• Weiss TL, Johnston JS, Fujisawa K, Okada S, Chappell J, Devarenne TP. Phylogenetic placement, genome size, and GC-content of the liquid hydrocarbon producing green microalga Botryococcus braunii var. Berkeley (Showa) (Chlorophyta). J. Phycol. 2010, 46, 534-540.
• Ueoka R, Ise Y, Ohtsuka S, Okada S, Yamori T, Matsunaga S.  Yaku'amides A and B, Cytotoxic Linear Peptides Rich in Dehydroamino Acids from the Marine Sponge Ceratopsion sp.   J. Am. Chem. Soc. 2010, 132, 17692-17694.
  
• Ando H,Ueoka R, Okada S, Fujita T, Iwashita T, Imai T, Yokoyama T, Matsumoto Y, van Soest RWM, Matsunaga S.  Penasins A-E, Long-Chain Cytotoxic Sphingoid Bases, from a Marine Sponge Penares sp.  J. Nat. Prod. 2010, 73, 1947-1950.
• Hamada T, Matsunaga S, Fujiwara M, Fujita K, Hirota H, Schmucki R, Guentert P, Fusetani N.   Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge.  J. Am. Chem. Soc. 2010, 132, 12941-12945.
• Nishimura S, Arita Y, Honda M, Iwamoto K, Matsuyama A, Shirai A, Kawasaki H, Kakeya H, Kobayashi T, Matsunaga S, Yoshida M. Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling.   Nat. Chem. Biol.  2010, 6, 519-527.
• Vairappan CS, Anangdan SP, Tan KL, Matsunaga, S.   Role of secondary metabolites as defense chemicals against ice-ice disease bacteria in biofouler at carrageenophyte farms.  J. Appl. Phycol.  2010, 22, 305-311.
  

2009

• Akiyama T, Ueoka R, van Soest RWM, Matsunaga S.  Ceratodictyols, 1-glyceryl ethers from the red alga-sponge association Ceratodictyon spongiosum/Haliclona cymaeformis  J. Nat. Prod.  2009, 72, 1552-1554. 
• Matsunaga S, Takahashi N, Fusetani, N.  Dinogunellins A-D: putative ichthyootoxic phospholipids of northern blenny Stichaeus grigorjewi eggs.  Pure  Appl. Chem.  2009, 81, 1001-1008. 
• Ueoka R, Ise Y, Matsunaga S.  Cytotoxic polyacetylenes related to petroformyne-1 from the marine sponge Petrosia sp.  Tetrahedron 2009, 65, 5204-5208.
  
• Takishima S, Ishiyama A, Iwatsuki M, Otoguro K, Yamada H, Omura S, Kobayashi H, van Soest RWM, Matsunaga S.   Merobatzelladines A and B, anti-infective tricyclic guanidines from a marine sponge Monanchora sp.  Org. Lett., 11, 2655-2658.
• Ueoka, R, Fujita T, Matsunaga, S.  Ophiodilactones A and B, Cytotoxic Tetrameric Phenylpropanoids, from the Ophiuroid Ophiocoma scolopendrina.  J. Org. Chem.  2009, 74, 4396-4399.
• Ueoka R, Nakao Y, Kawatsu S, Yaegashi J, Matsumoto Y, Matsunaga S, Furihata K, van Soest RWM, Fusetani N. Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis.   J. Org. Chem.  2009, 74, 4203-4207.
• Ueoka R, Ito A, Izumikawa M, Maeda S, Takagi M, Shin-ya K, Yoshida M, van Soest RWM, Matsunaga S.  Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.  Toxicon 2009, 53, 680-684.
• Yamashita T, Nakao Y, Matsunaga S, Oikawa T, Imahara Y, Fusetani N.  A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa.
  Bioorg. Med. Chem. 2009, 17, 2181-2184.
  

2008

• Ueoka R, Fujita T, Iwashita T, van Soest RWM, Matsunaga S.  Inconspicamide, new N-acylated serinol from the marine sponge Stelletta inconspicua.
  Biosci. Biotechnol. Biochem. 2008, 72, 3055-3058. 
• Araki T, Matsunaga S, Nakao Y, Furihata K, West L, Faulkner DJ, Fusetani N.Koshikamide B, a Cytotoxic Peptide Lactone from a Marine Sponge Theonella sp.  J. Org. Chem.  2008, 73, 7889-7894. 
• Miyata Y, Matsunaga S.  Structure elucidation of 21,22-dihydroxyonnamides A1-A4 from the marine sponge Theonella swinhoei: an empirical rule to assign the relative stereochemistry of linear 1,5-diols.  Tetrahedron Lett. 2008, 49, 6334-6336. 
• Trisciuoglio D, Uranchimeg B, Cardellina JH, Meragelman TL, Matsunaga S, Fusetani N, Del Bufalo D, Shoemaker R, Melillo Giovanni.  Induction of Apoptosis in Human Cancer Cells by Candidaspongiolide, a Novel Sponge Polyketide.  J. Natl. Cancer Inst. 2008, 100, 1233-1246.
• Nakao Y, Kawatsu S, Okamoto C, Okamoto M, Matsumoto Y, Matsunaga S, van Soest RWM, Fusetani N.  Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata. J. Nat. Prod. 2008, 71, 469-472
• Murayama S, Nakao Y, Matsunaga S.  Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex. Tetrahedron Lett. 2008, 49, 4186-4188
• Ueoka R, Nakao Y, Fujii S, van Soest RWM, Matsunaga S.  Aplysinoplides A-C, cytotoxic sesterterpenes from the marine sponge Aplysiopsis digitata. J. Nat. Prod. 2008, 71, 1089-1091

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